My laptop has dual drives in it, plus i have an external usb drive. All 3 of these are 2.5" notebook drives, which are designed for more vibration, motion, etc. They've been in my truck now for 3 years without a single issue.
However, I tried to put a standard computer in the truck. The computer had a standard 3.5" drive. It lasted exactly 1 day. I hit a bump on the interstate and killed the hard drive.