Hi Johnny,
Welcome to the forum!
Yes, you are correct, S&T Keys will not work with MS MapPoint 2006. It only works with MS Streets & Trips.
Mappoint is programmable, and programmers could create much better application for Mappoint than what I created for S&T. Streets & Trips is not pragmatically controllable, and all that S&T Keys can do is to try to simulate what a user would do with a mouse and a keyboard. It's not the best solution, but it works. More users use Streets & Trips for GPS navigation than MapPoint. Streets & Trips costs only about 10% of what MapPoint costs. Another advantage is that Streets & Trips (map data and software features) is updated annually vs. Mappoint only about once per two years.