Thank you for the reply. This is not a Marine GPS unit, so I do not know how to respond to your question.
I agree that the ArcGIS (ArcMap) and the MS Streets & Trips 2010 are not communicating with each other.
We have talked to the technicians with ESRI to see if they knew of something that is causing the crashing, but was unsuccessful.
I will gather more info and re-post later.
Thanks again to all.