I loaded Streets & Trips 2010 into my Acer One NAV50 with Windows 7 and it runs flawlessly. The computer is about 1 1/2 months old. The smaller screen takes some getting used to, however.
Generally speaking, I wouldn't buy the computer for everyday use, primarily because the keyboard is also smaller. It cuts my typing speed in half. Overall, it's a fine machine and does exactly what it's designed to do.